Purine compounds having PDE IV inhibitory activity and methods o

Details Purine compounds having PDE IV inhibitory activity and methods o Purine compounds having PDE IV inhibitory activity and methods o

1998-12-10

2000-05-02

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544314, 546118, 546297, C07D47334, C07D47104, C07D23946, C07D21375

Patent

active

060574453

ABSTRACT:
The present invention comprises methods of synthesizing compounds having the formula I: ##STR1## wherein: Y.sub.1, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.8 are as described herein, which comprises the steps of

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Rasmussen, Aus J. Chem 33, 535, 1982.
Er-Rhaimini, Tet. Letters 31, 5757, 1990.
Some New N-Methylpurines, Gertrude B. Elion, CIBA foundation Symp. Chem Biol. Purines, 1957, pp. 39-49.
Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogues, Michael J. Ashton, et al., Journal of Medicinal Chemistry, 1994, vol. 37, No. 11, pp. 1696-1703.
Synthesis of 3-Methylisoguanine [6-Amino-3-methylpurin-2(3H)-one], G.T. Rogers and T.L. B. Ulbricht, J. Chemical Soc.(C), 1971, pp. 2364-2366.
Synthesis of Potential Anticancer Agents. XIX. 2-Substituted N.sup.6 -Alkyladenines, John A. Montgomery, Lee B. Holum and Thomas P. JohnstonThe Kettering-Meyer Laboratory, Southern Research Institute, Aug. 5, 1959, vol. S. pp. 3963-3967.
The photosolvolysis of N-arylmethyladenines. Photoremovable N-arylmethyl protective groups for N-containing compounds., A. Er-Rhaimini, et al., Tetrahedron Letters, vol 31, No. 40, pp. 5757-5760, 1990.
Heterocyclic Ambident Nucleophiles. IV* The Alkylation of Metal Salts of Adenine, Malcolm Rasmussen, et al., Aust. J. Chem, 1982, 35, 535-42.

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