Purine compounds having PDE IV inhibitory activity and methods o

Details Purine compounds having PDE IV inhibitory activity and methods o Purine compounds having PDE IV inhibitory activity and methods o

1998-12-10

2000-03-21

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544322, 544329, C07D47334, C07D23948, C07D23942

Patent

active

060404477

ABSTRACT:
The present invention comprises a method of synthesizing compounds having the formula (I): ##STR1## wherein: Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.8 are defined herein, which comprises the steps of

REFERENCES:
Montgomery, J. Med Chem 15, 1189, 1972.
Some New N-Methylpurines, Gertrude B. Elion, CIBA foundation Symp. Chem Biol. Purines, 1957, pp. 39-49.
Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogues, Michael J. Ashton, et al., Journal of Medicinal Chemistry, 1994, vol. 37, No. 11, pp. 1696-1703.
Synthesis of 3-Methylisoguanine [6-Amino-3-methylpurin-2(3H)-one], G.T. Rogers and T.L.B. Ulbricht, J. Chemical Soc.(C), 1971, pp. 2364-2366.
Synthesis of Potential Anticancer Agents. XIX. 2-Substituted N.sup.6 -Alkyladenines, John A. Montgomery. Lee B. Holum and Thomas P. Johnston. The Kettering-Meyer Laboratory, Southern Research Institute, Aug. 5, 1959, vol. S. pp. 3963-3967.
N-Alkyl Derivatives of Purine-6(1H)-thione, John A. Montgomery, et al., Journal of Medicinal Chemistry, 1972, vol. 15, No. 11, pp. 1189-1192.

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