Purine and isosteric antibacterial compounds

Details Purine and isosteric antibacterial compounds Purine and isosteric antibacterial compounds

2005-08-09

2005-08-09

Berch, Mark L. (Department: 1624)

Compositions: coating or plastic

Coating or plastic compositions

Contains fireproofing or biocidal agent

C544S276000, C544S118000, C514S234200, C514S263200, C514S263370

Reexamination Certificate

active

06926763

ABSTRACT:
The invention features compounds of the formula:or a pharmaceutically acceptable salt thereof, wherein A is CR2and B is N; wherein n is 0-3; wherein R1is (CH2)m—{(G)o—(CH2)p}q—L, in which G is CH2, CH═CH, C≡C, CO, O, S, or NR5, where R5is H or C1-6alkyl, CHR6, where R6is OH or C1-6alkyl, CH(CR7R8), where each of R7and R8is, independently, H, halo, or C1-6alkyl, OCO, CONR9, NR10CO, where each of R9and R10is, independently, H or C1-6alkyl, SO2NH, or NHSO2; in which m is 1-4, o is 0-4, p is 0-4, and q is 0-4. The compounds disclosed herein have potent anti-microbial, e.g., both Gram-positive and Gram-negative anti-bacterial properties. The compounds inhibit DNA polymerase IIIC and DNA polymerase IIIE enzymes and thus act therapeutically by inhibiting the growth of a broad array of bacteria. The compounds can be administered to prevent or to treat Gram-positive or Gram-negative bacterial infections, e.g., in eukaryotic cell cultures, animals, or humans.

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