Purine-2,8-diones and pharmaceutically acceptable salts thereof

Details Purine-2,8-diones and pharmaceutically acceptable salts thereof Purine-2,8-diones and pharmaceutically acceptable salts thereof

1995-03-23

1997-08-19

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544265, A61K 3152, C07D47328

Patent

active

056589182

ABSTRACT:
The present invention provides purine derivatives and pharmaceutically acceptable salts thereof which exhibit an inhibitory action towards nasal mucus secretion and are useful as pharmaceuticals for treatment of nasal secretion and rhinitis. The purine derivatives are represented by the following general formula: ##STR1## wherein R is alkyl or cycloalkyl, or optionally-substituted phenyl or phenylalkyl; R' is hydrogen or --COOX; and X is alkyl, alkenyl, alkoxyalkyl, phenyl or phenylalkyl. The compounds are useful as therapeutic and preventive agents for various types of rhinitis accompanied by acceleration of nasal mucus secretion and by the sneezing reflex such as allergic rhinitis. The compounds may be administered orally and exhibit low toxicity, little side effect and high safety. Accordingly, continuous long term administration of the pharmaceutical compositions may be performed for highly effective treatment of rhinitis.

REFERENCES:
Takino, Chem Abs 91, 129036 (1979).
Takino, Chem Abs 105, 91339 (1986).
Brown, Chem Abs 54, 5682d (1960).
Bergmann, JACS, 82, 598 (1960).

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