Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Plant proteins – e.g. – derived from legumes – algae or...
Patent
1989-09-07
1991-12-31
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Plant proteins, e.g., derived from legumes, algae or...
530416, 530417, 530412, C07K 322, C07K 326, C07K 328, C07K 1510
Patent
active
050773909
ABSTRACT:
A substantially pure, hemagglutinin-free composition of trichosanthin, and a method of producing the composition is disclosed. A plant extract from Trichosanthes kirilowii is contacted with an anionic exchange resin to remove contaminating hemagglutinins, and trichosanthin is further purified from the extract by cation exchange chromatography to a purity of greater than 95%.
REFERENCES:
patent: 4705686 (1987-11-01), Scott et al.
patent: 4795739 (1989-01-01), Lifson et al.
Maraganore et al., 1987, J. Biol. Chem. 262(24):11628-11633.
Sofer, G., 1984, Bio/Technology, Dec., pp. 1035-1038.
Yeung, et al., 1986, Int. J. Peptide Protein Res. 27:325-333.
Yeung et al., 1987, Immunopharmacology and Immunotoxicology 9(1):25-46.
"ZetaPrep.RTM. Ion Exchange Chromatography", Life Sciences Division, of Cuno, Inc.
Soikes Raul R.
Wade Susan B.
Wu Paul S.
Dehlinger Peter J.
Fabian Gary R.
Furman Keith C.
Genelabs Incorporated
Moskowitz Margaret
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