Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1978-09-18
1981-02-10
Danison, Walter C.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424 95, 424177, C07G 700, A61K 3702
Patent
active
042500842
ABSTRACT:
Chemically substantially pure and uniform THF (thymic hormone), substantially devoid of endotoxins, having a molecular weight of 3323.sup..+-. 220, an isoelectric point of from 5.7 to 5.9; an amino acid composition of approximately: aspartic acid--4 units; threonine--1 unit; serine--5 units; glutamic acid--8 units; proline--2 units; glycine--5 units; alanine--2 units; leucine--1 unit; lysine--1 unit; arginine--2 units; 1/2 cystine--1 to 2 units; being the product of purification of thymus tissue and removal there from of endotoxins, and a process for the preparation of same which comprises:
REFERENCES:
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patent: 3657417 (1972-04-01), Brunetti et al.
patent: 4010148 (1977-03-01), Goldstein
patent: 4077949 (1978-03-01), Goldstein
Souadjian et al., Chemical Abstracts, vol. 75:32,928y (1971).
Comsa et al., Chemical Abstracts, vol. 53:2335a (1959).
Carnaud et al., J. Expl. Med., vol. 138 (1973), pp. 1521-1532.
Kook et al., Cellular Immunology, vol. 19, (1975), 151-157.
Trainin et al., J. Expl. Med., vol. 132, No. 5 (1970), 885-897.
Danison Walter C.
Yeda Research and Development Company Limited
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