Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...
Patent
1989-06-13
1990-10-23
Weimar, Elizabeth C.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Stablizing an enzyme by forming a mixture, an adduct or a...
435214, 424446, 424 9464, 128156, 128DIG22, C12N 996, C12N 974, A61F 1300, A61K 37547
Patent
active
049652036
ABSTRACT:
Improved thrombin formulations, stable at room temperature using stabilizing quantities of a polyol and a buffer at specific pHs are described wherein crude thrombin is first purified by two-stage ion exchange chromatography.
REFERENCES:
patent: 4363319 (1982-12-01), Altshuler
patent: 4515637 (1985-05-01), Cioca
patent: 4696812 (1987-09-01), Silbering et al.
Baughman , D. J. (1970) Met. in Enzymology 19, 145-157.
Blythe, Jr. Rowland P.
Fawzi Mahdi B.
Nesbitt, Jr. Russell U.
Silbering Steven B.
Daignault Ronald A.
Patterson Charles L.
Warner-Lambert & Company
Weimar Elizabeth C.
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