Purified protein which functions as a mycobacterial receptor for

Details Purified protein which functions as a mycobacterial receptor for Purified protein which functions as a mycobacterial receptor for

1994-06-24

1997-04-08

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530355, 530382, 5303881, 5303884, 53038885, 530825, 4241301, 4241431, 4241641, 4241681, 4242481, C07K 100, A61K 39395

Patent

active

056189168

ABSTRACT:
A method for the treatment of superficial urinary tract tumors in a mammal involves administering a diagnostically effective amount of a liposomal composition comprising a liposome, a chemotherapeutic agent or immune activating drug carried by the liposome and a purified protein which functions as a mycobacterial receptor for fibronectin on the surface of the liposome whereby the liposomal composition becomes attached to and internalized in the cells of the tumors. In lieu of the purified protein an antibody to an integrin receptor on the surface of the cells of the tumors may be used or a delivery system composed of a conjugate of a chemotherapeutic agent or immune activating drug and an antibody to an integrin receptor may be employed.

REFERENCES:
patent: 5194257 (1993-03-01), Ratliff et al.
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Aslanzadeh et al, Chemical Abstracts, vol. 112, p. 444, Ref. #4445c, 1990 (J. Gen. Microbiol. 1989, 135 (10), 2735-41).
Ratliff et al, J. Gen. Microbiol., vol. 134, pp. 1307-1313, 1988.
Hudson et al, Chemical Abstracts, vol. 115, p. 32, Ref. #8496:a, 1991 (Cancer Res. 1991, 51(14) 3726-32).
Valentin. Weigand et al, Chemical Abstracts, vol. 116, p. 444, Ref. #231763f, 1992 (Res. Microbiol. 1992, 143 (1), 75-9).
Godfrey et al, Infection and Immunity, vol. 60, No. 6, pp. 2522-2528, Jun. 1992.
Rao et al, Infection and Immunity, vol. 60, No. 9, pp. 3652-3657, Sep. 1992 .

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