Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1995-04-10
1998-05-19
Scheiner, Toni R.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
435 723, 436 64, 530350, G01N 33574, G01N 3353
Patent
active
057535221
ABSTRACT:
A composition useful in a method for diagnosing cancer-associated retinopathy including the steps of acquiring a purified aliquot of 26 kDa protein, and, utilizing the protein, or a unique fragment thereof, to perform a patient-serum assay to identify in a sample of a patient's serum the presence of autoantibodies to the 26 kDa protein autoantigen.
REFERENCES:
patent: 5405749 (1995-04-01), Polans et al.
Dizhoor, A.M., et al., Science, vol. 251, pp. 915-918, 22 Feb. 1991.
D. Denny-Brown, "Primary sensory neuropathy with muscular changes associated with carcinoma," J. Neurol. Neurosurg. Psychiatr., 11:73-87, 1948.
W.R. Brain et al., "Subacute cortical cerebellar degeneration and its relation to carcinoma," J. Neurol. Neurosurg. Psychiatr., 14:59-75, 1951.
A.M. Crestfield et al., "The preparation and enzymatic hydrolysis of reduced and S-carboxymethylated proteins," J. Biol. Chem., 238:622-627, 1963.
P.B. Croft et al., "Carcinomatous neuromyopathy: its incidence in patients with carcinoma of the lung and carcinoma of the breast," Lancet, i:184-188, 1963.
L. Brain et al., The remote effects of cancer on the nervous system, Grune & Stratton, New York, 1965.
L. Brain et al., "Subacute cerebellar degeneration associated with neoplasms," Brain, 88:465-478, 1965.
C.Y. Lai, "Studies on the structure of rabbit muscle aldolase. I. Cleavage with cyanogen bromide: an approach to the determination of the total primary structure," Arch. Biochem. Biophys., 128:202-211, 1968.
F. Norris, "The remote effects of cancer on the nervous system," Z. Neurol., 201:201-210, 1972.
M. Bradford , "A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding," Anal. Biochem., 72:248-254, 1976.
R.A. Sawyer et al., "Blindness caused by photoreceptor degeneration as a remote effect of cancer," Am. J. Ophythalmol., 81:606-613, 1976.
A.S. Polans et al., "Light-induced dephosphorylation of two proteins in frog rod outer segments. Influence of cyclic nucleotides and calcium," J. Gen. Physiol., 74:595-613, 1979.
S.C. Schold et al., "Subacute motor neuronopathy: A remote effect of lymphoma," Ann. Neurol., 5:271-287, 1979.
R.J. Hawley et al., "The carcinomatous neuromyopathy of oat cell lung cancer," Ann. Neurol., 7:65-72, 1980.
R.A. Henson et al., "Cancer and the nervous system: the Neurological manifestations of systemic malignant disease," Blackwell Scientific, Oxford, 346-367, 1982.
S.E. Kornguth et al., "Occurrence of anti-retinal ganglion cell antibodies in patients with small cell carcinoma of the lung," Cancer, 50:1289-1293, 1982.
Paul A. Bunn et al., "Paraneoplastic syndromes. In cancer: Principle and practice of oncology," J.B. Lippincott & Co., Philedelphia, 1797-1842, 1982.
D.S. Papermaster, "Preparation of retinal rod outer segments," Methods Enzymol., 81:48-52, 1982.
U. Wildon et al., "Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites," Biochemistry, 21:3014-3022, 1982.
J.L. Keltner et al., "Photoreceptor degeneration: possible autoimmune disorder," Arch. Ophthalmol. 101:564-569, 1983.
T.A.S. Buchanan et al., "An ultrastructural study of retinal photoreceptor degeneration associated with bronchial carcinoma," Am. J. Ophthalmol., 97:277-287, 1984.
G.B. Grunwald et al., "Autoimmune basis for visual paraneoplastic syndrome in patients with small-cell lung carcinoma," Lancet, i:658-661, 1985.
J. Newsom-Davis, "Lambert-Eaton myasthenic syndrome," Sem. Immunopathol, 8:129-140, 1985.
J.W. Crabb et al., "Complete primary structure of prostatropin, a prostate epithelial cell growth factor," Biochemistry, 25:4988-4993, 1986.
G.M.P. Galbraith et al., "Antibodies to neurofilament protein in retinitis pigmentosa," J. Clin. Invest., 78:865-869, 1986.
J.E. Greenlee et al., "Anti-cerebellar antibodies in serum and cerebrospinal fluid of a patient with oat cell carcinoma of the lung and paraneoplastic cerebellar degeneration," Ann. Neurol., 19:82-85, 1986.
P. Matsudaira, "Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes," J. Biol. Chem., 262:10035-10038, 1987.
H. Schagger et al., "Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range of 1-100kDa," Anal. Biochem., 166:368-379, 1987.
C.E. Thirkill et al., "Cancer-associated retinopathy," Arch Ophthalmol, 105:372-375, 1987.
N.E. Anderson et al., "Paraneoplastic cerebellar degeneration: clinical-immunologic correlations," Ann. Neurol., 24:559-567, 1988.
J.W. Crabb et al., "The complete primary structure of the cellular retinaldehyde-binding protein from bovine retina," J. Biol. Chem., 263:18678-18687, 1988.
H.J. DeAizpurua et al., "Antagonism of voltage-gated calcium channels in small cell carcinomas of patients with and without Lambert-Eaton myasthenic syndromes by autoantibodies, w-conotoxin and adenosine," Cancer Res., 48:4719-4724, 1988.
Y.I. Kim et al., "IgG from patients with Lambert-Eaton syndrome blocks voltage-dependent calcium channels," Science (Wash. D.C.), 239:405-408, 1988.
A.S. Polans et al., "Sialoglycoproteins of the frog rod outer segmnet plasma membrane," Invest. Ophythalmol Vis. Sci. 29:1523-1532, 1988.
M.D. Burton et al., "The use of gold reagents to quantitate antibodies eluted from nitrocellulose blots: application to EM immunocytochemistry," Anal. Biochem., 183:225-230, 1989.
D. Gurne et al., "Antiretinal antibody in serum of patients with age-related macular degeneration," Invest. Ophthalmol. Vis. Sci., 30:366a, 1989.
C.E. Thirkill et al., "Cancer-associated retinopathy (CAR syndrome) with antibodies reacting with retina, optic-nerve and cancer cells," N. Engl. J. Med., 321:1589-1594, 1989.
M.O.M. Tso, "Experiments on visual cells by nature and man: in search of treatment for photorecptor degeneration," Invest. Ophthalmol. vis. Sci., 30:2430-2460, 1989.
H.F. Furneaux et al., "Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes," Neurology, 40:1085-1091, 1990.
J. Huang et al., "Application of sodium dodecyl sulfate-gel electrophoresis to low molecular weight polypeptides," Anal. Biochem., 188:114-117, 1990.
K.A. West et al., "Current Research in Protein Chemistry," J.J. Villagranca, editor, 37-48, 1990.
Arthur S. Polans et al., "A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy," J. Cell Biol., 112:981-989, 1991.
Palczewski Krzysztof
Polans Arthur S.
Legacy Good Samaritan Hospital And Medical Center
Scheiner Toni R.
LandOfFree
Purified protein for identifying a cancer-associated retinopathy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Purified protein for identifying a cancer-associated retinopathy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Purified protein for identifying a cancer-associated retinopathy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1852345