Purified protease nexin

Details Purified protease nexin Purified protease nexin

1990-09-05

1992-02-11

Therkorn, Ernest G.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210656, 530413, 530417, B01D 1508

Patent

active

050873687

ABSTRACT:
The gene encoding protease nexin I (PN-I) is cloned and expressed to provide practical quantities of PN-I for diagnostic and therapeutic use. PN-I is a serine protease inhibitor useful in controlling conditions mediated by proteolytic activity.

REFERENCES:
Scott, Protease Nexin, the Journal of Biological Chemistry, vol. 260, No. 11, Jun. 10, 1985, pp. 7029-7034.
Scott, Purification of Human Protease Nexin, vol. 258, No. 17, Sep. 10, 1983, pp. 10439-10444.
Proteases in Biological Control (1975) Reich et al., eds. Cold Spring Harbor, N.Y., pp. 1-10 (1975).
Jones et al., (1980) Cancer Research 40:3222-3227 "Destruction of Extracellular Matrices Containing Glycoprote in ".
Bergman et al., (1986) Proc. Natl. Acad. Sci. U.S.A. 83:996-1000, "Inhibition of Tumor-Cell-Medicated Extracellular Matrix".
McGuire-Goldring et al., (1984) ARth. Rheum. 27:S24 Abstract 51.
Monrad et al., (1983) Prog Brain Res 58:359-364 Inhibition of Protease Activity Can Lead to Neurite Extension.
Scott, R. W., Chemical Abstracts, 103, No. 3, (1985), "Protease Nexin. Properties and Modified Purification Procedure".
Eaton, D. L., Chemical Abstracts, 101, No. 7, (1984), "Purification of Human Fibroblast Urokinase Proenzyme and Analysis of its Regulation by Proteases and Protease Nexin".
Gloor, S., Biological Abstracts, 83, No. 7, (1987), "A Glia-Derived Neurite Promoting Factor with Protease Inhibitory Activity Belongs to the Protease Nexins".
Erickson, L. A., Proc Natl Acad Sci, 82:8710-8714, (1985), "The Primary Plasminogen-Activator Inhibitors in Endothelial Cells, Platelets, Serum, and Plasma are Immunologically Related".
Ny, T. et al., Proc Natl Acad Sci, 83:6776-6780, (1986), "Cloning and Sequence of a cDNA Coding for the Human Beta-Migrating Endothelial-Cell-Type Plasminogen Activator Inhibitor".

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