Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-08-12
1999-03-30
Sidberry, Hazel
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530355, 530380, 5303881, 53038824, 5303911, 530399, 530413, 514 2, C07K 1449, C07K 1622, A61K 3818, A61K 3824
Patent
active
058891498
ABSTRACT:
Monoclonal antibodies (MAbs) capable of binding to native PDGF, and MAbs capable of specifically binding to the PDGF-AA, PDGF-BB and PDGF-AB isoforms are disclosed. The subject MAbs may be used in the detection or purification of native PDGF or selected PDGF isoforms. In addition, the MAbs may be labeled with an imaging agent and used for in vivo diagnostic purposes, or combined with a pharmaceutically acceptable carrier or diluent for use within wound healing compositions.
REFERENCES:
patent: 4376110 (1983-03-01), David et al.
patent: 4415665 (1983-11-01), Mosbach et al.
patent: 4479896 (1984-10-01), Antoniades
patent: 4689220 (1987-08-01), Sturmer et al.
patent: 4766073 (1988-08-01), Murray et al.
patent: 4769328 (1988-09-01), Murray et al.
patent: 4801542 (1989-01-01), Murray et al.
patent: 4845075 (1989-07-01), Murray et al.
patent: 4849407 (1989-07-01), Murray et al.
patent: 5030565 (1991-07-01), Niman et al.
patent: 5094941 (1992-03-01), Hart
patent: 5128321 (1992-07-01), Murray et al.
patent: 5175255 (1992-12-01), Thomason et al.
Waterfield et al., "Platelet-Derived Growth Factor is Structurally Related to the Putative transforming protein p28 .sup.sis of Human Simian Sarcoma Virus", Nature 304:35-39, 1983.
Raines et al., "Platelet-Derived Growth Factor", J. Bio. Chem. 257:5154-5159, 1982.
Deuel et al., "Human Platelet-Derived Growth Factor", J. Bio. Chem. 256:8896-8899, 1981.
Antoniades, "Human Platelet-Derived Growth Factor (PDGF):Purification of PDGF-I and PDGF-II and Separation of Their reduced Subunits", Proc. Natl. Acad. Sci. USA 78:7314-7317, 1981.
Johnsson et al., "Platelet-Derived Growth Factor: Identification of Constituent Polypeptide", Biochem. and Biophys. Research Comm. 104:66-74, 1982.
Kelly et al., "The B Chain of PDGF Alone is Sufficient for Mitogenesis", EMBO J. 4:3399-3405, 1985.
Niman, "Antisera to a Synthetic Peptide of the sis Viral Oncogene Product Recognize Human Platelet-Derived Growth Factor" Nature 307:180-183, 1984.
Betsholtz et al., "cDNA Sequence and Chromosomal Localization of Human Platelet-Derived Growth Factor A-Chain and its Expression in Tumor Cell Lines", Nature 320:695-699, 1986.
Tong et al., "cDNA Clones Reveal Differences Between Human Glial and Endothelial Cell Platelet-Derived Growth Factor A-Chains", Nature 328:619-621, 1987.
Robson et al., "Predictions of the Conformation and Antigenic Determinants of the V-sis Oncogene Product Homologous with Human Platelet-Derived Growth Factor", Int. J. Peptide Protein Res. 25:1-8, 1985.
Knudsen, "Proteins Transferred to Nitrocellulose for Use as Immunogens", Anal. Biochem. 147:285-288, 1985.
Carbon et al., "Selection of Specific Clones from Colony Banks by Screening with Radioactive Antibody", Meth. in Enzymol. 68:436-442, 1979.
Brown et al., "Protein Antigens of Normal and Malignant Human Cells Identified by Immunoprecipitation with Monoclonal Antibodies", J. Biol. Chem. 255:4980-4983, 1980.
Alber and Kawasaki, "Nucleotide Sequence of the Triose Phosphate Isomerase Gene of Saccharomyces cerevisiae", J. Mol. and Appl. Genet. 1:419-434, 1982.
Kurjan and Herskowitz, "Structure of a Yeast Pheromone Gene (MF.alpha.): A Putative .alpha.-Factor Precursor Contains Four Tandem Copies of mature .alpha.-Factor", Cell 30:933-943, 1982.
Beggs, "Transformation of Yeast by a Replicating Hybrid Plasmid", Nature 275:104-108, 1978.
Kohler and Milstein, "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature 256:495-497, 1975.
Kohler and Milstein, "Derivation of Specific Antibody-Producing Tissue Culture and Tumor Lines by Cell Fusion", Eur. J. Immunol. 6:511-519, 1976.
Clark, "Fundamental Concepts in Immunobiology", Immunology, Wiley & Sons, Inc. (1980) pp. 5-6.
Sprugel et al., "Platelet-Derived Growth Factor and Impaired Wound Healing", Clinical and Experimental Approaches to Dermal and Epidermal Repair: Normal and Clinical Wounds, Wiley-Liss, (1991) pp. 327-340.
Metzgar et al Journal of Cellular Biochemistry Suppl 10C Abstracts, 1986 Abst L131.
Hart et al Journal of Cellular Biochem. Suppl. 11A, Abstracts 1987 Abst A126.
Kawahara et al Biochemical & Biophysical Res Comm. 147:839-845, 1987.
Kelley et al EMBO J. 4:399-3405 1985.
Niman et al Nature 307:180-183 1984.
Metzgar et al (Zeleznik et al) Journal of Cellular Biochemistry Suppl. 10C Abstracts 1986 Abst L131.
LandOfFree
Purified PDGF AB isoform and method of making it does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Purified PDGF AB isoform and method of making it, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Purified PDGF AB isoform and method of making it will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1216241