Purified pancreatic tumor cell lines and related compositions an

Details Purified pancreatic tumor cell lines and related compositions an Purified pancreatic tumor cell lines and related compositions an

1998-03-18

1999-11-16

Burke, Julie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Cancer cell or component thereof

424 9321, 424 937, 424 851, 435 695, 435 701, 435375, 435384, 435369, 435405, 435406, 536 235, A61K 3539, C07H 2104

Patent

active

059852909

ABSTRACT:
The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a cytokine relative to the unmodified tumor cell line, and (c) administering the tumor cell line to a mammalian host having at least one tumor that is the same type of tumor as that from which the tumor cell line was obtained, wherein the tumor cell line is allogeneic and is not MHC-matched to the host. The present invention also provides a pancreatic tumor cell line, a method and medium for obtaining such a tumor cell line, and a composition comprised of cells of a purified pancreatic tumor cell line.

REFERENCES:
patent: 4595653 (1986-06-01), Kroneberg
patent: 5342774 (1994-08-01), Boon et al.
patent: 5399346 (1995-03-01), Anderson et al.
Browning et al Cell vol. 72 847-856, Mar. 1993.
Johnson et al Cancer Treatment Review vol. 2 1-31, 1975.
Gura et al Science vol. 278 1041-1042, Nov. 1997.
Ellem et al Cancer Immunol Immunother vol. 44 10-20, 1997.
Paul et al Fundamental Immunology Third Edition Chapter 21 p. 826, 1993.
de Vroede et al., Endocrinology, 114:1917-1929 (1984).
Heaton et al., Endocrinology, 118: 2555-2560 (1986).
Maurer et al., Animal Cell Culture: A Practical Approach, Chapter 2, IRL Press, 13-31 (1986).
Rechler et al., Horm Res., 24:152-159 (1986).
Rosenthal et al., J. Endocrinology, 141, 69-74 (1994).
Shimizu, Am. J. Physiol., 251, E611-615 (1986).
Sinclair et al., Blood 72(1):66-72 (Jul. 1988).
Darrow et al., J. Immunol., 142, 3329-3335 (1989).
Gastl et al., Cancer research, 52, 6229-6236 (1992).
Golumbek et al., Cancer Research, 53, 5841-5844 (1993).
Hom et al., J. Immunother., 10, 153-164 (1991).
Huang et al., Science, 264, 961-965 (1994).
Itaya et al., Cancer Research, 47, 3136-3140 (1987).
Jaffee et al., Cancer Research, 53, 2221-2226 (1993).
Jaffee et al., Seminars in Oncology, 22, 81-91 (1995).
Kalthoff et al., Contrib. Oncol., 50, 101-110 (1995).
Kawakami et al., J. Immunol., 148, 638-643 (1992).
Nabel et al., Proc. Natl. Acad. Sci. USA, 90, 11307-11311 (1993).
Ostrand-Rosenberg et al., Int. J. Cancer: Supplement, 6, 61-68 (1991).
Plautz et al., Proc. Natl. Acad. Sci. USA, 90, 4645-4649 (1993).
Szuromi (ed.), Science, 264, 885 (1994).
Database WPI, Week 7808, Derwent Info Ltd., AN 77-09702Y/06 (JP 53-003-509 abstract). (Jan. 1978).
Database WPI, Week 8928, Derwent Info Ltd., AN 89-206442/28 (WO 89/05631 abstract). (1989).
Database WPI, Week 9035, Derwent Info Ltd., AN 90-266194/35 (JP 2-188-532 abstract). (Jul. 1990).
Database WPI, Week 9250, Derwent Info Ltd., AN 92-415476/50 (WO 92/20374 abstract). (1992).
Database WPI, Week 9317, Derwent Info Ltd., AN 93-136183/17 (EP 538,952 abstract). (Apr. 1993).
Database WPI, Week 9432 and 9518, Derwent Info Ltd., AN 94-264105/32 (WO 94/17192 abstract). (1994).
Database WPI, Week 9503, Derwent Info Ltd., AN 95-022468/03 (WO 94/27635 abstract). (1994).
Database WPI, Week 9536, Derwent Info Ltd., AN 94-169430/21 (EP 599,077 abstract). (1994).

Affiliated with

Also associated with

Rating

Purified pancreatic tumor cell lines and related compositions an does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Purified pancreatic tumor cell lines and related compositions an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Purified pancreatic tumor cell lines and related compositions an will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1320763