Purified, native dystrophin

Details Purified, native dystrophin Purified, native dystrophin

1991-01-16

1995-07-04

Redding, David A

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Glycoprotein, e.g., mucins, proteoglycans, etc.

530397, 530413, 530414, 530416, 530417, C07K 320, C07K 322, C07K 310

Patent

active

054301297

ABSTRACT:
The invention pertains to pure, native dystrophin of mammalian skeletal muscle and a method of purifying dystrophin from mammalian skeletal muscle. The invention further pertains to a method of diagnosing muscular dystrophy by detecting the loss or abnormal structure of pure, native dystrophin from mammalian skeletal muscle. The detection of a loss of dystrophin or an abnormal structure of dystrophin is indicative of muscular dystrophy.

REFERENCES:
patent: 4912202 (1990-03-01), Campbell et al.
patent: 5187063 (1993-02-01), Campbell et al.
patent: 5239060 (1993-08-01), Kunkel et al.
Korsgren et al., Jour. of Biol. Chem., vol. 261(12), pp. 5536-5543, 1986.
Koenig et al., Cell, 53: 219-228 (1988).
Hoffman et al., Cell, 51: 919-928 (1987).
Ervasti et al., Nature 345: 315-319 (1990).
Campbell et al., Nature 338: 259-262 (1989).
Ervasti et al., J. Biol. Chem., 266: 9161-9165 (1991).
Ohlendieck, K. et al., J. Cell Biol. vol. 112, No. 1, Jan. 1991, pp. 135-148.
Campbell et al., Nature vol. 338, 1989, pp. 259-262.

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