Purified myeloblastin, nucleic acid molecule encoding same, and

Details Purified myeloblastin, nucleic acid molecule encoding same, and Purified myeloblastin, nucleic acid molecule encoding same, and

1989-12-22

1993-01-19

Lacey, David L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530350, 5303879, 53038826, 435 6, 435 691, C07H 1512, C07K 300, C12Q 168, A61K 3700

Patent

active

051808196

ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding human myeloblastin, a nucleic acid probe for detecting myeloblastin, and an antisense oligodeoxynucleotide complementary to myeloblastin mRNA. The invention also provides antibodies directed to myeloblastin, and purified myeloblastin. The invention further provides a pharmaceutical composition to inhibit proliferation and induce differentiation of leukemia cells, a myeloblastin inhibitor, and a factor suppressing myeloblastin expression. The invention provides methods for identifying leukemia cells which express different quantities of myeloblastin, treating leukemia, and for preparing purified myeloblastin.

REFERENCES:
patent: 4795700 (1989-01-01), Dervan et al.
Bories et al. (1989) Cell, vol. 59, pp. 959-968.
Cayre et al. (1987) PNAS vol. 84, pp. 7619-7623.
Solomon et al. (1988) PNAS, vol. 85, pp. 6904-6908.
Koeffler (1983) Blood, vol. 62, pp. 709-721.
Takahashi et al. (1988, Feb.), JBC, vol. 263, pp. 2543-2547.
Holt et al. (1988, Feb.), Molecular and Cellular Biology, vol. 8, pp. 963-973.
Agrawal, S., et al., Proc. Natl. Acad. Sci. USA, vol. 86, pp. 7790-7794 (1989) (Exhibit A).
Heikkila, R., et al., Nature, vol. 328, pp. 445-449 (1987) (Exhibit D).
Wickstrom, E., et al., In Vitro Cellular & Developmental Biology, vol. 24, pp. 297-302 (1989) (Exhibit G).
Wickstrom, E., et al., Proc. Natl. Acad. Sci. USA, vol. 85, pp. 1028-1032 (1988) (Exhibit H).

Affiliated with

Also associated with

Rating

Purified myeloblastin, nucleic acid molecule encoding same, and does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Purified myeloblastin, nucleic acid molecule encoding same, and , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Purified myeloblastin, nucleic acid molecule encoding same, and will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-102909