Purified multimerase

Details Purified multimerase Purified multimerase

1996-05-31

2000-05-30

Eisenchenk, Chris

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9467, 435212, 435217, 435814, A61K 3848, A61K 3846, C12N 948, C12N 950

Patent

active

060688386

ABSTRACT:
There is disclosed a purified multimerase having an indirect and a direct proteolytic activity, which converts vWF having a singlet structure to vWF having a satellite structure and is active in the presence of the serine protease inhibitor DFP or the calpain protease inhibitor Z-Leu-Leu-Tyr-CHN.sub.2, as well as a method of preparing the multimerase according to the invention.

REFERENCES:
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U.K. Laemli, Nature, 227: 680-685 (Aug. 15, 1970).
M. Furlan et al., Proc. Natl. Acad. Sci. USA, 90: 7503-7507 (Aug. 1993).
B. Fischer et al., FEBS Letters, 375: 259-262 (1995).
Furlan et al. Blood 87(10): 4223-4234, May 15, 1996.
Tsai Blood 87(10):4235-4244, May 15, 1996.
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Berkowitz et al. Blood 72(5): 1790-1796 (Nov. 1988).
Furlan et al. Blod 87(10): 4223-4234 (May 1996).
Furlan et al. Thombosis Research vol. 10: 153-158, 1977.
Furlan et al. PNAS 90: 7503-7507, 1993.

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