Purified mite allergen

Details Purified mite allergen Purified mite allergen

1994-08-04

1996-03-05

Budens, Robert D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

424 981, 4242751, 435 4, 435 721, 435 792, 436543, 436544, 436545, 436546, 530395, A61K 3935, C07K 1400

Patent

active

054965543

ABSTRACT:
New purified mite allergens useful as pharmaceutical and diagnostic compositions for the treatment and diagnosis of mite allergic diseases are provided. Both allergens are contained in fecal extracts of mites in culture. The high molecular weight allergen has a weight average molecular weight of 70,000 to 80,000 as determined by sedimentation equilibrium. This is a glycoprotein containing more than about 70% sugar, and possesses allergen activity. The low molecular weight antigen has a molecular weight of 1,500 to 5,000 as determined by Sephadex G25 gel filtration. This is a glycoprotein containing more than about 40% sugar, and also possesses allergen activity.

REFERENCES:
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