Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-04-26
2005-04-26
Horlick, Kenneth R. (Department: 1637)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S024310, C536S024320, C536S024330, C530S350000, C435S320100, C435S325000, C435S069100
Reexamination Certificate
active
06884877
ABSTRACT:
Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
REFERENCES:
Marks et al., Dermatitis from cashew nuts, Journal of the American Academy of Dermatology, Apr., 1984, pp. 627-631, vol. 10, No. 4.
Burks et al., Atopic dermatitis and food hypersensitivity reactions, The Journal of Pediatrics, Jan., 1998, pp. 132-136, vol. 132, No. 1.
Tariq et al., Cohort study of peanut and tree nut sensitisation by age of 4 years, The Bellevue Guide to Outpatient Medicine, Aug. 31, 1996, pp. 514-517, vol. 313, No. 7056.
Garcia et al., Allergy to Anacardiaceae: Description of cahsew and pistachio nut allergens, Invest Allergol Clin Immunol, May-Jun. 2000, pp. 173-177, vol. 10, No. 3.
Fernandez et al., Allergy to pistachio: crossreactivity between pistachio nut and other Anacardiaceae, Clinical and Experimental Allergy, 1995, pp. 1254-1259, vol. 25.
Parra et al., Pistachio nut hypersensitivity: identification of pistachio nut allergens, Clinical and Experimental Allergy, 1993, pp. 996-1001, vol. 23.
Burks et al., Mapping and mutational analysis of the IgE-binding epitopes on Ara h 1, a legume viciin protein and a major allergen in peanut hypersensitivity, Eur. J. biochem. 1997, pp. 334-339, vol. 245.
Chomczynski et al., Single-step Method of RNA Isolation by Acid Guanidinum Thiocyanate-Phenol-Chloroform Extraction, Analytical Biochemistry, 1987, pp. 156-159, vol. 162.
Sze-Tao et al., Effects of processing and storage on walnut (Juglans regia L) tannis, Journal of the Science of Food and Agriculture, 2001, pp. 1215-1222, vol. 81.
Robotham et al., Linear IgE epitope mapping of the Enlgish walnut (Juglans regia) major food allergen, J Allergy Clin Immunol, Jan. 2002, pp. 143-149, vol. 109, No. 1.
Marcus et al., A family of antimicrobial peptides is produced by processing of a 7S globulin protein in Macadamia Integrifolia kernels, The Plant Journal, 1999, pp. 699-710, vol. 19, No. 6.
Grimes, et al., A 62-kD Sucrose Binding Protein Is Expressed and Localized In Tissues Actively Engaged In Sucrose Transport, The Plant Cell, Dec. 1992, pp. 1561-1574, vol. 4.
Teuber et al., Identification and cloing of a complementary DNA encoding a vicilin-like proprotein, Jug r 2, from English walnut kernel (Juglans regia), a major food allergen, J Allergy Clin Immunol, Dec. 1999, pp. 1311-1320, vol. 104, No. 6.
Rabjohn et al., Molecular cloning and epitope analysis of the peanut allergen Ara h3, The Journal of Clinical Investigation, Feb. 1999, pp. 535-542, vol. 103, No. 4.
Helm et al., Mutational analysis of the IgE-binding epitopes of P34/Gly m Bd 30K, J Allergy Clin Immunol, Feb. 2000, pp. 378-384, vol. 105, No. 2, Pt. 1.
Stanley et al., Identification and Mutational Analysis of the Immunodominant IgE Binding Epitopes of the Major Peanut Allergen Ara h 2, Archives of Biochemistry and Biophysics, Jun. 15, 1997, pp. 244-253, vol. 342, No. 2.
Beezhold et al., Mutational analysis of the IgE epitopes in the latex allergen Hev b 5, J Allergy Clin Immunol, Jun. 2001, pp. 1069-1076, vol. 107, No. 6.
Heiss et al., Component-Resolved Diagnosis (CRD) of Type I Allergy with Recombinant Grass and Tree Pollen Allergens by Skin Testing, The Journal of Investigative Dermatology, Nov. 1999, pp. 830-837, vol. 113, No. 5.
Valenta et al., Genetically Engineered and Synthetic Allergen Derivatives: Candidates for Vaccination against Type I Allergy, Biol. Chem., Jul./Aug. 1999, pp. 815-824, vol. 380.
Bannon, et al., Engineering, Characterization and in vitro Efficacy of the Major Peanut Allergens for Use in Immunotherapy, Int. Arch Allergy Immunol, 2001, pp. 70-72, vol. 124.
Niedergerger et al., Skin Test Results bu not Serology Reflect Immediate Type Respiratory Sensitivity: A Study Performed with Recombinant Allergen Molecules, The Journal of Investigative Dermatology, Oct. 2001, pp. 848-851, vol. 117, No. 4.
Bhalla et al., Reduction in Allergenicity of Grass Pollen by Genetic Engineering, Int. Arch. Allergy Immunol, 2001, pp. 51-54, vol. 124.
Nordlee et al., Identification of a Brazil-Nut Allergen in Transgenic Soybeans, The New England Journal of Medicine, Mar. 14, 1996, pp. 688-692, vol. 334, No. 11.
Maleki et al., Structure of the Major Peanut Allergen Ara h 1 May Protect IgE-Binding Epitopes from Degradation, The Journal of Immunology, 2000, pp. 5844-5849, vol. 164.
Van Kampen et al., Analysis of B-Cell Epitopes In The N-Terminal Region of Chi t I Component III Using Monoclonal Antibodies, Molecualr Immunology, 1994, pp. 1133-1140, vol. 31, No. 15.
Breiteneder et al., Complementary DNA cloning and expression inEscherichia coliof Aln I, the major allergen in pollen of alder (Alnus glutinosa), J. Allergy Clin. Immunol., Dec. 1992, pp. 909-917, vol. 90, No. 6, Pt. 1.
Ball et al., A major continuous allergenic epitope of bovine B-lactoglobulin recognized by human IgE binding, Clinical and Experimental Allergy, 1994, pp. 758-764, vol. 24.
Aas et al., Physico-Chemical Properties And Specific Activity Of A Purified Allergen (Codfish), Inernational WHO-IABS Symposium on Standardization and Control of Allergens Administered to Man, Geneva 1974 / Cevelop. Biol. Standard, pp. 90-98, vol. 29.
Elsayed et al., Synthetic Allergenic Epitopes from the Amino-Terminal Regions of the Major Allergens of Hazei and Birch Pollen, Int Arch Allergy Appl Immunol, 1989, pp. 410-415, vol. 89.
Herian et al., Identification of Soybean Allergens by Immunoblotting with Sera from Allergic Adults, Int Arch Allergy Appl Immunol, 1990, pp. 193-198, vol. 92.
Shanti et al., Identification of Tropomyosin as the Major Shrimp Allergen and Characterization of its IgE-Binding Epitopes, The Journal of Immunology, Nov. 15, 1993, pp. 5354-5363, vol. 151.
Schramm et al., Discontinuous IgE-binding epitopes contain multiple continuous epitope regions: results of an epitope mapoing on recombinant Hol 1 5, a major allergen from velvet grass pollen, Clinical and Experimental Allergy, 2001, pp. 331-341, vol. 31.
Vila et al., Role of conformational and linear epitopes in the achievement of tolerance incow's milk allergy, Clinical and Experimental Allergy, 2001, pp. 1599-1606, vol. 31.
Bredehorst et al., What establishes a protein as an allergen?, Journal of Chromatography B, 2001, pp. 33-40, vol. 756.
Sicherer et al., A voluntary registry for peanut and tree mut allergy: Characteristics of the first 5149 registrants, J. Allergy Clin. Immunol, Jul. 2001, pp. 128-132, vol. 108, No. 1.
Pelikan, Z. M.D., F.A.C.A, The Diagnostic Approach To Immediate Hypersensitivity In Patients With Allergic Rhinitis; A comparison of Nasal Challenges And Serum Rast, Annals of Allergy, Sep. 1983, pp. 395-400, vol. 51.
Bousquet et al., Nasal challenge with pollen grains, skin-prick tests and specific IgE in patients with grass pollen allergy, Clinical Allergy, 1987, pp. 529-536, vol. 17.
Kuusisto et al., Comparison of immunologic tests in the diagnosis of occupational asthma and rhinitis, Allergy, 1994, pp. 342-347, vol. 49.
Roux Kenneth H.
Sathe Shridhar K.
Teuber Suzanne S.
Florida State University Research Foundation, Inc.
Horlick Kenneth R.
Wilder Cynthia
LandOfFree
Purified linear epitopes from cashew nuts, nucleic acids... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Purified linear epitopes from cashew nuts, nucleic acids..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Purified linear epitopes from cashew nuts, nucleic acids... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3427147