Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1986-06-04
1990-08-07
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 7, 435 7021, 4351722, 435948, 424 858, 935 95, 935100, 935102, 935103, 935104, 935106, 935107, 935108, 935110, 530387, 530388, C12N 500, C12N 1500, A61K 3900, C12P 2100
Patent
active
049467883
ABSTRACT:
The invention relates to novel purified human immunoglobulin E binding factors (IgE-BFs), its individual optionally glycosylated proteins, and fragments thereof, processes for the purification of IgE-BFs, novel monoclonal antibodies to lymphocyte cellular receptors for IgE (Fc.sub..epsilon. R) crossreacting with IgE-Fs, derivatives thereof, processes for the preparation of these antibodies and their derivatives, hybridoma cell lines that produce these antibodies, processes for the preparation of said hybridoma cell lines, the use of the monoclonal antibodies and their derivatives for the qualitative and quantitative determination of IgE-BFs, test kits containing the monoclonal antibodies and/or their derivatives, the use of the monoclonal antibodies for the purification of IgE-BFs, the use of purified IgE-BFs, its individual optionally glycosylated proteins and/or fragments thereof for the prevention and/or treatment of allergy, and to pharmaceutical preparations containing them. IgE-BFs and monoclonal antibodies reacting with IgE-BF are important for the diagnosis and therapy of allergic diseases.
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C. Rocha et al., The Journal of Allergy and Clinical Immunology 73, 151 (1984) (Abstract No. 172).
T. F. Huff and K. Ishizaka, Proc. Natl. Acad. Sci, U.S.A. 81, p. 1514 (1984).
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Ciba-Geigy Corporation
Fishman Irving M.
Krupen Karen I.
Nucker Christine M.
Villamziar JoAnn
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