Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1994-02-10
1996-04-30
Low, Christopher S. F.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530350, 930290, 935 9, 935 11, 536 235, 4241391, C07K 1447, A61K 3817
Patent
active
055126600
ABSTRACT:
The present invention relates to intercellular adhesion molecules (ICAM-2) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
REFERENCES:
patent: 5284931 (1994-02-01), Springer et al.
Rothlein et al. 1986. J. Immunol. 137, 1270-1274.
Borrebeck, C. A. K., Strategy for the production of human monoclonal antibodies using in vitro activated B cells, J. Immunol. Methods 123:157-165 (1989).
Rudinger, J., Characteristics of the amino acids as components of a peptide hormone sequence in Parsons, J. A., ed., Peptide Hormones, University Park Press, Baltimore, pp. 1-7 (Jun. 1976).
Li, R. et al., A Peptide from ICAM-2 Binds to the Leukocyte Integrin CD11a/CD18 and Inhibits Endothelial Cell Adhesion, J. Biol. Chem. 268(23):17513-17518 (Aug. 15, 1993).
Dustin Michael L.
Springer Timothy A.
Staunton Donald E.
Dana Farber Cancer Institute, Inc.
Low Christopher S. F.
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