Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2006-05-30
2006-05-30
Murphy, Joseph (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
C435S007100
Reexamination Certificate
active
07053184
ABSTRACT:
AE. colirecombinant plasmid expressing a fusion protein having the human erythropoietin receptor extracellular domain is disclosed. A purified fusion protein produced from such a vector is also disclosed, the fusion protein having a cleavage site suitable for separating the erythropoietin receptor extracellular domain from the remainder of the fusion protein. Antibodies having specific binding affinity for a purified extracellular domain polypeptide are also disclosed. The purified human erythropoietin receptor fragment polypeptide binds erythropoietin. The articles, compositions and methods of the invention are useful for studying ligand binding to erythropoietin receptor and for quantitating the amounts of erythropoietin receptor, as well as for understanding receptor structure and signal transduction.
REFERENCES:
patent: 5378808 (1995-01-01), D'Andrea, et al.
Harris, K. W., et al. (1992)J. Biol. Chem. 267: 15205-09.
Elliot et al. Activation of the EPO Receptor by Bivalent anti-EPO-Receptor Antibodies. Journal of Biological Chemistry. vol. 271, No. 40. Oct. 1996, pp. 24691-24697.
Sambrook et al. Molecular Cloning, vol. 3, (pp. 16.3-16.5, 16.17-16.18)). 1989.
Jones et al. Human Erythropoietin Receptor: Cloning, Expression, and Biologic Characterization. Blood, vol. 76, No. 1, Jul. 1990, pp. 31-35.
Hamud Fozia
McTavish Hugh
Murphy Joseph
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