Purified human cytomegalovirus protein

Details Purified human cytomegalovirus protein Purified human cytomegalovirus protein

1993-02-12

1994-05-24

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

43524027, 530413, C12Q 170, C12N 520, C07K 318

Patent

active

053148002

ABSTRACT:
A purified human CMV virion protein that has a molecular weight of approximately 86,000 daltons by SDS-PAGE and exhibits in vivo. immunizing activity and a murine monoclonal antibody that binds specifically to the protein and exhibits complement-independent human CMV neutralizing activity are described. The antibody is useful for isolating the protein by affinity chromatography and the protein is, in turn, useful for detecting CMV neutralizing antibody in sera and as a vaccine.

REFERENCES:
patent: 4743562 (1988-05-01), Rasmussen et al.
patent: 5194256 (1993-03-01), Rasmussen et al.

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