Purified human cytomegalovirus protein

Details Purified human cytomegalovirus protein Purified human cytomegalovirus protein

1984-08-21

1988-05-10

Tarcza, John E.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436548, 530387, 424 89, 935104, 935110, 4351722, 43524026, 435948, C12N 500, C12N 1500, A61K 39245, A61K 3942

Patent

active

047435623

ABSTRACT:
A purified human CMV virion protein that has a molecular weight of approximately 86,000 daltons by SDS-PAGE and exhibits in vivo immunizing activity and a murine monoclonal antibody that binds specifically to the protein and exhibits complement-independent human CMV neutralizing activity are described. The antibody is useful for isolating the protein by affinity chromatography and the protein is, in turn, useful for detecting CMV neutralizing antibody in sera and as a vaccine.

REFERENCES:
patent: 4196265 (1980-04-01), Koprowski et al.
Goldstein et al., Infection and Immunity 38 pp. 273-281 (1982).
Sarov et al., Virology 66, pp. 464-473 (1975).
Gupta et al., Journal of General Virology 34 pp. 447-454 (1977).
Schmitz et al., Intervirology 13, pp. 154-161 (1980).
Pereira et al., Infection and Immunity 36, pp. 924-932 (1982).
Rasmussen et al., "Murine Monoclonal Antibody to a Single Protein Neutralizes the Infectivity of Human Cytomegalovirus", Proceedings of the National Academy of Sciences 81, pp. 876-880 (2-1984).
Dalchau et al., "The Purification of Antigens and Other Studies with Monoclonal Antibody Affinity Columns" in, Monoclonal Antibodies in Clinical Medicine ed. McMichael et al. 1982, pp. 519-521.
Fiala et al., Journal of Virology 19, pp. 243-254 (1976).
Kim et al., Journal of Virology 19, pp. 604-611 (1976).

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