Purified human cytomegalovirus protein

Details Purified human cytomegalovirus protein Purified human cytomegalovirus protein

1987-10-02

1993-03-16

Lacey, David L.

Drug, bio-affecting and body treating compositions

Lymphokine

530350, 530806, 530826, 435236, A61K 3912, C07K 1504, C12N 704

Patent

active

051942569

ABSTRACT:
A purified human CMV virion protein that has a molecular weight of approximately 86,000 daltons by SDS-PAGE and exhibits in vivo immunizing activity and a murine monoclonal antibody that binds specifically to the protein and exhibits complement-independent human CMV neutralizing activity are described. The antibody is useful for isolating the protein by affinity chromatography and the protein is, in turn, useful for detecting CMV neutralizing antibody in sera and as a vaccine.

REFERENCES:
patent: 3959466 (1976-05-01), Plotkin
patent: 4196265 (1980-05-01), Koprowski et al.
patent: 4689225 (1987-08-01), Pereira
Fiala, M., et al., J. Virology (1976) 19:243-254.
Stinski, J. Virology (1976) 19:594-609.
Kim, K. S., V. J. Sapienza, et al, J. Virology (1976) 20:604-611.
Rasmussen, L., et al., Proc Natl Acad Sci (USA) (1984) 81:876-880.
Dalchau, R., et al., Monoclonal Antibodies in Clinical Medicine, McMichael and Fabre, Editors, Acadamic Press 1983, p. 520.
Pereira, L., et al., Infection and Immunity (1982) 36:933-942.
Goldstein, L., et al., Infection and Immunity (1982) 38: 273-281.
Kim, K., et al., J Clinical Microbiology (1983) 18:331-343.
Sarov, I. Virology (1975) 66:464-473.
Gupta, P. et al., J. Gen Virol (1977) 34:447-454.
Schmitz, H., et al. Intervirology (1980) 13:154-161.

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