Purified galactomannan as an improved pharmaceutical excipient

Details Purified galactomannan as an improved pharmaceutical excipient Purified galactomannan as an improved pharmaceutical excipient

1995-06-07

2000-05-16

Peselev, Elli

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

514 54, 514169, 514177, 514782, 536114, 536124, A61K 920, C07M 100

Patent

active

060634022

ABSTRACT:
Disclosed is a substantially anhydrous, powdered, galactomannan composition consisting essentially of a galactomannan hydrocolloid exhibiting about 50% to about 90% by weight of anhydromannose residues and about 10% to about 50% by weight anhydrogalactose residues; less than about 1% by weight of protein material and less than about 3% of other nonaqueous impurities. This material is useful for preparing pharmaceutical compositions both in the substantially anhydrous form but preferably in an anhydrated form which includes about 5-15% by weight water. The pharmaceutical compositions comprise a therapeutically effective amount of a drug, the hydrated powered gallactomannan composition and optionally other pharmaceutically-acceptable excipients. When the hydrated powdered purified glactomannan of the invention is used to form a tablet, one sees improved hardness in the tablet formed. The pharmaceutical composition of the invention is particularly valuable for delivering a therapeutically effective drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition. Unique means to prepare the purified galactomannan in large quantities is provided.

REFERENCES:
patent: 5234825 (1993-08-01), McCeary et al.
Ikari, et al. "The Effect of Soluble Fiber Dietary Supplement on Constipation in 3 Patients with Dysphagia Who Suffered From Cerebral Infarction with Special Reference to Serum Diamine Oxidase Activity" Jpn. J. Geriat 1993, 30:402.
Chowdhury et al., (1988) "Single Step Purification of Polysaccharides Using Immoblilzed Jackfruit Lectin as Affinity Adsorbent" Glycoconjugate 5:27-34.
Noble et al., (1990) "Rheological Properties of Galactomannan-Based Gels. Part 1--Guar and Hydroxypropylguar Gels in Alkaline Media" Carbohydrate Polymers 12:203-217.

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