Purified forms of DNASE

Details Purified forms of DNASE Purified forms of DNASE

1992-06-08

1994-01-18

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435199, 435814, 435815, C12N 922, A61K 3754

Patent

active

052798232

ABSTRACT:
The present invention provides the identification and characterization of two components of a recombinant preparation of DNase. These components are the purified deamidated and non-deamidated human DNases. Taught herein are the separation of these components and the use of the non-deamidated species as a pharmaceutical per se, and in particular in compositions wherein the species is disclosed within a plastic vial, for use in administering to patients suffering from pulmonary distress.

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Wright, Protein Engineering, 4(3):283-294 (1991).

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