Purified form of streptogramins, its preparation and pharmaceuti

Details Purified form of streptogramins, its preparation and pharmaceuti Purified form of streptogramins, its preparation and pharmaceuti

1995-06-07

1997-06-10

Johnson, Jerry D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530344, A61K 3804, A61K 3808, C07K 130, C07K 132

Patent

active

056375654

ABSTRACT:
This invention relates to a purified form of streptogramins, consisting of a combination of one or more group B components of streptogramins, of general formula: ##STR1## in which A.sub.1 is a radical of general formula: ##STR2## for which R' is H or OH and Y is H, a methylamino radical or a dimethylamino radical, R is an ethyl radical or, when R' is H, R can also represent --CH.sub.3, and R.sub.1 and R.sub.2 are H, or alternatively A.sub.1 is a radical of formula: ##STR3## R is an isobutyl radical, and R.sub.1 is OH and R.sub.2 is --CH.sub.3, and one or more group A minority components of streptogramins, of general formula: ##STR4## in which R" is H or a methyl or ethyl radical, in the state of cocrystallizate, of a coprecipitate or of a physical mixture of the powders.

REFERENCES:
patent: 4618599 (1986-10-01), Corbet et al.
patent: 4668669 (1987-05-01), Barriere et al.
patent: 4798827 (1989-01-01), Barriere et al.
J. Preud'Homme, et al., "Pristinamycine isolement, caracterisation et identification des constituants", pp. 585-591, Bulletin de la Societe Chimique de France, 1968, vol. 2.
N.K. Sharma et al., "Isolation of factor A (viginamycin M1) and factor B (mixture of VS1 and VS4) from a commercial fee additive formulation", Chemical Abstracts, vol. 110, No. 7, Feb. 13, 1989, abstract No. 56082.

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