Purified flavonoid and diterpene 5.alpha.-reductase inhibitors f

Details Purified flavonoid and diterpene 5.alpha.-reductase inhibitors f Purified flavonoid and diterpene 5.alpha.-reductase inhibitors f

1996-06-07

1998-06-30

Naff, David M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514456, 514557, 514681, 514729, A61K 3578, A61K 3112, A61K 3119, A61K 3135

Patent

active

057730059

ABSTRACT:
Strong 5.alpha.a-reductase inhibitors are extracted and fractionated from Thuja orientalis and other similar crude drugs or they may be purified as diterpenes in isolated form. The inhibitors are used either on their own or as active ingredients of therapeutics in the treatment of diseases caused by the overactivity of 5.alpha.a-reductase or the hypersecretion of androgens, such as male pattern baldness, androgenetic alopecia, hirsutism, acne, prostatomegaly and cancer of the prostate.

REFERENCES:
Inoue et al. Terpenoids from the seed of Platycladus orientalis, Phytochemistry 24:1602-1604, 1985.
Muhammad et al. Further antibacterial diterpenes from the bark and leaves of Juniperus procera Hochst. ex Endl., Phytotheraphy Research, 9:584-588, 1995.

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