Purified extract of uvaria brevistipitata and a process for obta

Details Purified extract of uvaria brevistipitata and a process for obta Purified extract of uvaria brevistipitata and a process for obta

1995-04-20

1997-03-04

Rollins, John W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514885, 514894, 514934, A61K 3578

Patent

active

056076738

ABSTRACT:
In HIV infected individuals, certain clinical and biological markers are used to assess the progression or regression of the disease. From the plant, Uvaria bevistipitata of the Annonaceae family, a substantially pure extract was derived. This extract was administered to 268 HIV infected patients in a clinical trail in Zaire Africa and dramatic results were obtained. The extract was also submitted to a laboratory for in vitro analysis. when tested against the HIV reverse transcriptase enzyme, the extract tested 96.7% active. In further laboratory analysis, against HIV-.sub.IIB, it demonstrated efficacy at doses that showed no cytotoxic effects.

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