Purified enterotoxin receptor protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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435 691, 4353701, C07K 1300, C12N 1512

Patent

active

052370518

ABSTRACT:
RNA has been cloned for the intestinal receptor which recognizes heat stable enterotoxins and has guanylyl cylase activity. The protein sequence has been deduced. The protein has been expressed in cultured cells. Data shows that the protein binds enterotoxin and signals normally through the cyclic GMP second messenger system.

REFERENCES:
Cell. vol. 63, pp. 941-948, Nov. 30, 1990, Schulz et al. Guanylyl Cyclase is a Heat-stable Enterotoxin Receptor.
J. Biol. Chem. 261 (3) pp. 1470-1476, Jan. 25, 1986, Kuno et al. Characterization of the Receptor for Heat-Stable Enterotoxin from Escherichia coli Cell in Rat Intestines.

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