Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1990-12-06
1993-08-17
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 4353701, C07K 1300, C12N 1512
Patent
active
052370518
ABSTRACT:
RNA has been cloned for the intestinal receptor which recognizes heat stable enterotoxins and has guanylyl cylase activity. The protein sequence has been deduced. The protein has been expressed in cultured cells. Data shows that the protein binds enterotoxin and signals normally through the cyclic GMP second messenger system.
REFERENCES:
Cell. vol. 63, pp. 941-948, Nov. 30, 1990, Schulz et al. Guanylyl Cyclase is a Heat-stable Enterotoxin Receptor.
J. Biol. Chem. 261 (3) pp. 1470-1476, Jan. 25, 1986, Kuno et al. Characterization of the Receptor for Heat-Stable Enterotoxin from Escherichia coli Cell in Rat Intestines.
Garbers David L.
Schulz Stephanie
Hill Jr. Robert J.
Ulm John D.
Vanderbilt University
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