Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1989-09-08
1991-03-05
Teskin, Robin L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4352402, 435 694, 435 691, 935 13, 935 70, C12P 2100, C12N 1500, C07H 1512
Patent
active
049979299
ABSTRACT:
A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF(SN-CNFT) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract.
Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described.
Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF.
REFERENCES:
Collins, Devel. Biol., vol. 109, pp. 255-258, 1985, "Electrophoretic Similarity of the Ciliary Ganglion Survival Factors from Different Tissues and Species".
Manthorpe et al., Brain Res., vol. 367, pp. 282-286, 1986, "Purification of Adult Rat Sciatic Nerve Ciliary Neurotrophic Factor".
Hughes et al., Nature, vol. 335:70, 1988.
Ebendal, Chem. Abst., vol. 106, No. 150248h, 1987, "Comparative Screening for Ciliary Neurotrophic Activity in Organs of the Rat and Chicken".
Lillien et al., Type-2 Astrocyte Development in Rat Brain Cultures is Initiated by a CNTF-like Protein Produced by Type-1 Astrocytes Neuron, vol. 1, 485-494, Aug. 1988.
Collins Franklin D.
Lin Leu-Fen
Synergen, Inc.
Teskin Robin L.
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