Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1984-08-20
1985-12-17
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
260112R, A61K 3700, C07G 700
Patent
active
045593256
ABSTRACT:
Highly purified fractions from human urine exhibiting antineoplastic activity and processes for their preparation are described. The fractions comprise biologically active, small sized, low molecular weight peptides which exert cytostatic and cytotoxic activity toward neoplastic cell cultures and human neoplastic diseases. The fractions have been termed antineoplaston fractions. An antineoplastic active peptide common to each of the various antineoplaston fractions has been isolated and identified as 3-[N-phenylacetylaminopiperidine]-2, 6-dion. A synthetic mechanism for the preparation of 3-[N-phenylacetylaminopiperdine]-2,6-dion is also disclosed, involving a combination reaction between L-glutamine and phenylacetyl chloride. Also disclosed are the hydrolysis degradation products of 3-[N-phenylacetylaminopiperidine]-2, 6-dion which also exhibit antineoplastic activity when administered according to the general teachings presented in this disclosure.
REFERENCES:
patent: 4470970 (1981-12-01), Burzynski
Stein, W. H. et al., "Phenylacetylglutamine as a Constituent of Normal Human Urine", J. Amer. Chem. Soc., 70:2848-9, (1954).
Burzynski, S. R. et al., "Purification, Structure Determination, Synthesis and Animal Toxicity Studies of Antineoplaston A10", 13th International Congress of Chemotherapy, (Aug.-Sep. 1983).
Antineoplastons, Unlisted Drugs 28:133, (Aug. 1976).
Kamerling, J. P. et al., "Gas Chromatography of Urinary N-Phenylacetylglutamine", J. Chromatography, 164:217-221, (1979).
Pinkston, D., J. Chromatography, 223:1-19, (1981).
Chem. Abstr., vol. 95, (1981), 20593k.
Gross, et al., "Urinary Peptides in Muscular Dystrophy" Physiol: Chem. & Phys. 8: 161-166, (1976).
Burzynski, et al., "Biologically Active Peptides in Human Urine: III, Inhibitors of the Growth of Human Leukemia, Osteosarcoma, and HELA Cells," Physiol. Chem. & Phys., 8:13-22, (1976).
Burzynski, et al., "Biologically Active Peptides in Human Urine: II, Effect of Intestinal Smooth Muscle and Heart", Physiol. Chem. & Phys., 6:457-468, (1974).
Burzynski, et al., "Biologically Active Peptides in Human Urine," Physiol. Chem. & Phys., 5:437-447, (1971).
Neish, W. J. P., "Phenylacetic Acid as a Potential Therapeutic Agent for the Treatment of Human Cancer: Experientia 27:860, (1971).
James, M., et al., "Conjugates of Phenylacetic Acid with Taurine and Other Amino Acids in Various Species" Proceedings of the Biochemical Society, 124: 15P, (1971).
Hirom, et al., "Glutamine Conjugation of Phenylacetic Acid in the Ferret" Biochemical Society Transactions, 5:1033, (1977).
Sheple et al., "The Fate of Some of the Phenyl-Acetylated Amino-Acids in the Animal Organism" J. Biol. Chem., 53:463-478, (1922).
Beall, et al., "Polypeptides That Inhibit Human Breast Cancer Cell Division" Cancer Biochem. Biophys. 3:93-96, (1979).
Burzynski, S. R., "Antyneoplastony" Pryeglad Lekarski 6: 583-586, (1978).
Burzynski, et al., "Urinary Peptides Inhibit DNA Synthesis in Vitro in Certain Cultured Neoplastic Cells," Clinical Chemistry 23: 148-149, (1977).
Burzynski, et al., "Antineoplaston A in Cancer Therapy (I)" Physiol Chem. & Physics, 9: 485-500, (1977).
Burzynski, S. R., "Antineoplastons: Biochemical Defense Against Cancer" Physiol. Chem. & Phys., 8:275-279, (1976).
Chem. Abstracts 14934(d), 1964.
Chem. Abstracts 63:7095(c), (1965).
Federation Proceedings Abstracts 35:3, (Mar. 1, 1976).
International Cancer Research Data Bank, Abstract No. 183, (May 1, 1976).
Federation Proceedings Abstracts, 32:3112, (Mar. 1973).
Lichtenstein, et al., "Antitumor Activity of Aromatic Acyl Derivatives of Amino Acids" Israel J. Med. Sci., 13:316, (1977).
Barbieri, et al., "Investigations on the Effect of Antitumor Peptides and Mixtures of Same" Estratto da Bollettino Chimico Farmaceutico 111:216, (1972).
Mardle, et al., "Reactive Acyl Dipeptides as Potential Penicillen Analogues, Part I,-(Acylaminosuccinimido)-Carboxylic Acids" J. Chem. Soc., 237-242, (1968).
LandOfFree
Purified antineoplaston fractions and methods of treating neopla does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Purified antineoplaston fractions and methods of treating neopla, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Purified antineoplaston fractions and methods of treating neopla will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2175072