Purified antigen from non-A, non-B hepatitis causing factor

Details Purified antigen from non-A, non-B hepatitis causing factor Purified antigen from non-A, non-B hepatitis causing factor

1985-03-08

1987-06-16

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

424 86, 424 89, 435 7, 435810, 436543, 436547, 436820, 530395, 530826, A61K 3929, C12Q 170, G01N 33531, G01N 33576

Patent

active

046736344

ABSTRACT:
The present invention discloses an isolated and purified antigen specific to non-A, non-B hepatitis (NANBH) causing agent. The utility of the antigen as a diagnostic serologic marker and as a screening device for detecting the carrier or source of non-A, non-B hepatitis or infective factor thereof, particularly in a blood bank or plasmapheresis setting and preventing transmission of NANBH by isolating the source is described. Use of the antigen as vaccine to induce protective antibodies capable of neutralizing NANBH infectivity is also disclosed. A kit for detecting the presence or identifying the carriers or sources of non-A, non-B hepatitis or causative agent thereof is also disclosed.

REFERENCES:
patent: 4464474 (1974-08-01), Coursaget et al.
Feinstone, et al., Non-A, Maybe-B Hepatitis, N. Engl. J. Med., 1984, 311:185-188.
Shirachi, et al., Hepatitis "C" Antigen in Non-A, Non-B Post-Transfusion Hepatitis, Lancet, (10/21/78), 854-6.
Deinhardt, et al., Viral Hepatitis, Bulletin of the World Health Organization, 60(5):661-691, (1982).
Tabor, E., Developments in Non-A, Non-B Hepatitis Screening, Lab World, 31:25-27, 1980.
Suh, et al., Specificity of an Immunoprecipitin Test for Non-A Non-B Hepatitis, Lancet, (1/24/81), 178-80.
Prince, et al., Long-Incubation Post-Transfusion Hepatitis Without Serological Evidence of Exposure to Hepatitis-B Virus, Lancet, (8/03/74), 241-6.
Alter et al., Clinical and Serological Analysis of Transfusion-Associated Hepatitis, Lancet, (11/01/75), 838-41.

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