Purified AIDS-associated virus ARV-2

Details Purified AIDS-associated virus ARV-2 Purified AIDS-associated virus ARV-2

1984-08-15

1987-12-29

Naff, David M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 7, 435235, 435243, 435810, 436518, 436528, 436543, 436808, 436809, 436811, 436825, 436826, G01N 33543, C12N 700, C12N 500

Patent

active

047161027

ABSTRACT:
A newly discovered family of AIDS-associated viruses, designated ARV, is described. The viruses were isolated from AIDS patients from San Francisco and (a) are type D retroviruses; (b) have Mg.sup.++ -dependent reverse transcriptase activity; (c) induce human multinucleated cells without immortalizing the cells; (d) are replicable in HUT-78 human T cells; and (e) induce viral protein(s) in HUT-78 that binds to Ig from AIDS patients. The infected HUT-78 cells and immunogenic polypeptides derived from the viruses are useful for diagnosing AIDS.

REFERENCES:
patent: 4520113 (1985-05-01), Gallo
Levy et al., Virology, 147, pp. 441-448 (1985).
Sanchez-Pescador et al., "AIDS: Papers from Science, 1982-1985", 410-427, 1985.
Rabson et al., Cell, 40, 477-480 (1985).
Pope, J. W., et al, N Engl J. Med (1983), 309:944.
Poiesz, B. J., et al, PNAS (1980), 77:7415.
Barre-Sinoussi, F., Science (1983).
Vilmer, E., et al, Lancet (1984) i:753.
Popovic, M. G., et al, Science (1984), 224:497.
Gallo, R. C., et al, Science (1984), 224:500.

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