Purifications of B-cell inducing factor (BIF) and B-cell growth

Details Purifications of B-cell inducing factor (BIF) and B-cell growth Purifications of B-cell inducing factor (BIF) and B-cell growth

1984-01-03

1988-03-08

Marantz, Sidney

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

435 7, 435 68, 43524027, 530412, 530416, 530417, C07K 320, C12P 2100, C12N 500

Patent

active

047300361

ABSTRACT:
Highly purified T cell replacing factor (TRF or BIF) essentially free of IL-2 and Interferon activities is obtained in the invention. BIF is useful for treatment of immunoregulatory disorders and/or stimulation of production of immunoglobulins. A method for production of BIF and BGF is described.
B cell lines for BIF assays are described as well as an assay for B cell receptor variants and a method for obtaining B cell variants from a variety of source materials.

REFERENCES:
patent: 4596774 (1986-06-01), Chang
patent: 4613459 (1986-09-01), Cantor
patent: 4624917 (1986-11-01), Sugimoto
patent: 4661447 (1987-04-01), Fabricius
patent: 4675383 (1987-06-01), Bohlen
Teranishi, T. et al., J. Immunol., 128(4), 1903-1908 (1982).
Falkoff, R. J. M. et al., J. Immunol., 129(1), 97-102 (1982).
Yoshizaki, K. et al., J. Immunol., 128(3), 1296-1301 (1982).
Muraguchi, A. et al., J. Immunol., 129(3), 1104-1107 (1982).
Ralph, P. et al., J. Immunol., 132(4), 1858-1862 (1984).

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