Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide
Reexamination Certificate
2004-03-11
2011-12-27
Swartz, Rodney P. (Department: 1645)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using a micro-organism to make a protein or polypeptide
C435S041000, C424S009100, C424S009200, C424S184100, C424S234100, C424S251100, C424S256100
Reexamination Certificate
active
08084235
ABSTRACT:
The present invention relates to a method for purifying bacterial cytolysins such as pneumococcal pneumolysin. A single chromatography step produces excellent purification of the cytolysin by binding soluble aggregated cytolysin to a hydrophobic interaction chromatography material in the presence of detergent and high salt.
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Biemans Ralph
Goraj Karine
Mertens Emmanuel
Vandercammen Annick
Campen Virginia G.
GlaxoSmithKline Biologicals S.A.
Swartz Rodney P.
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