Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1998-01-09
1999-06-29
Burn, Brian M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
544172, 546239, 548572, C07C22952, C07D29500, C07D21134, C07D20704
Patent
active
059170867
ABSTRACT:
A method for the purification of a keto acid having the general formula ##STR1## wherein R1 and R2 independently represent a straight or branched chain alkyl of 1-18 carbon atoms, a cycloalkyl of 4-8 carbon atoms or a phenyl both of which may be substituted by at least one substituent selected from the group consisting of halogen atoms and alkyls having 1-4 carbon atoms, an aralkyl of 7-10 carbon atoms, alkoxyalkyl having 2-20 carbon atoms, tetrahydrofuryl alkyl, alkylcarboxy alkyl, alkyl carboxy benzyl, or R1 and R2 together with the adjacent nitrogen atom may form a heterocyclic ring, or one of R.sub.1 and R.sub.2 is hydrogen, which comprises slurrying the keto acid with an alcohol solvent, maintaining the slurry at elevated temperature in a sealed vessel until the Rhodamine impurity has dissolved, cooling and isolating the pure keto acid by filtration.
REFERENCES:
patent: 5371285 (1994-12-01), Kondo et al.
Encyclopedia of Separation Technology, vol. 1, Douglas M. Ruthven, ed., John Wiley & Sons, 1997, pp. 814-815.
Chem. Abst. 121:35021.
Derwent Abstract 75-00537W.
Henshall John Barry
Taylor James Philip
Whitworth John
Burn Brian M.
Ciba Specialty Chemicals Corporation
Davis Brian J.
Mansfield Kevin T.
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