Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Plant proteins – e.g. – derived from legumes – algae or...
Patent
1988-02-16
1990-08-07
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Plant proteins, e.g., derived from legumes, algae or...
530350, 530370, 530391, 530415, 530417, 424 8591, C07K 1500
Patent
active
049469436
ABSTRACT:
The invention herein is directed to methods using Procion dyes to perform separations of interest in manipulating the NAD.sup.+ -independent ribotoxins. The methods are useful for preparing therapeutic agents contaning these ribotoxins of their A polypeptide components. This separation method has been applied in particular to preparing hybrid toxins containing ricin toxins, both of purifying the resulting products and also for separating the components intended to be used in the preparation of these end products. In addition, a novel ricin isotoxin prepared using the method of the invention is disclosed.
REFERENCES:
Funatsu et al, Agric. Biol. Chem. 42(4) 1978 pp. 851-859,
Mise et al. Agric. Biol. Chem., 41(10) 1977 pp 2041-2046.
Vidal et al. Int. J. Cancer, 36(6), 1985 pp. 705-711 (Biones abstract).
Appukuttan et al., Biochimica et Biophysica Acta, 580:10-14 (1979).
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