Purification of polysaccharide-protein conjugate vaccines by ult

Details Purification of polysaccharide-protein conjugate vaccines by ult Purification of polysaccharide-protein conjugate vaccines by ult

1998-12-29

2000-11-14

Housel, James C.

Chemistry: analytical and immunological testing

Including sample preparation

Liberation or purification of sample or separation of...

536127, 42419711, 4241931, G01N 118, C07G 1700, A61K 39385

Patent

active

061469025

ABSTRACT:
Disclosed and claimed are a method for the purification of polysaccharide-protein conjugate vaccines by ultrafiltration in a saturated solution of ammonium sulfate. The ultrafiltration method of the present invention provides an efficient, readily scalable method for removal of unbound polysaccharides from polysaccharide-protein vaccines, thereby improving the purity and consistency of the polysaccharide-protein vaccines.

REFERENCES:
patent: 4456691 (1984-06-01), Stark
patent: 4780409 (1988-10-01), Monji et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5153312 (1992-10-01), Porro
Concise Encyclopedia Chemistry, (Eds) Jacubke et al., Walter de Gruyter Berlin, New York, p. 876, 1994.
Whitfiled et al. J. Bacteriol. 174: 4913-4919, 1992.
Zalipsky et al. Biotechnol. Appl. Biochem. 15: 100-114, 1992.
Muzykantov et al. Anal. Biochem. 169: 383-389, 1988.
Chuet al., (1991) Infect. Immun., vol. 59, pp. 4450-4458.
Bartlett, (1959) Journal of Biological Chemistry, vol. 234, pp. 466.
Lowry et al., (1951) Journal of Biological Chemistry, vol. 193, pp. 265.
Aragon et al., (1993) Vaccine, vol. 11, pp. 552-557.
Isbell et al., (1987) Carbohydrate Research, vol. 161, pp. 181-193.
Park et al., (1949) J. Biol. Chem., vol. 181, pp. 149.
Dick et al., (1989) Conjugate Vaccines. Contrib. Microbiol. Immunol., vol. 10, pp. 48-114.

Affiliated with

Also associated with

Rating

Purification of polysaccharide-protein conjugate vaccines by ult does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Purification of polysaccharide-protein conjugate vaccines by ult, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Purification of polysaccharide-protein conjugate vaccines by ult will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2064033