Purification of plasminogen

Details Purification of plasminogen Purification of plasminogen

1974-02-14

1976-03-09

Moyer, Donald B.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

260112B, A61K 3514, A61K 3516, C07G 700, C07G 7026

Patent

active

039432459

ABSTRACT:
The purification of plasminogen from human and non-human mammalian plasma or Cohn Fraction III by modified affinity chromotography using Sepharose-L-lysine with high ionic strength buffer solutions as in ion exchange chromatography is described. A plasminogen is produced in great yield having unexpectedly enhanced activity toward N.sup..alpha.-CBZ-L-lysine p-nitrophenyl ester, enhanced fibrinolytic activity and significantly less contamination by unknown colloidal substances.

REFERENCES:
patent: 3234106 (1966-02-01), Hink, Jr.
Brockway et al., J. Biol. Chem., 246, pp. 4641-4647 (1971).
Science, 170, pp. 1095-1096 (1970).
Chemical Abstracts, Vol. 80:67938g and 142556m (1974).

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