Purification of pertussis antigens

Details Purification of pertussis antigens Purification of pertussis antigens

1987-01-20

1988-11-15

Schain, Howard E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 88, 530396, 530399, 530406, 530417, 530825, A61K 3910, C07K 312, C07K 328

Patent

active

047845899

ABSTRACT:
A process is provided for the production of lymphocytosis promoting factor (LPF), filamentous haemagglutinin (FHA) and at least one fimbrial agglutinogen from a liquid culture of Bordetella pertussis, which comprises the steps of (a) separating the culture into cellular and supernatant fractions, (b) concentrating the supernatant fraction, (c) fractionating the concentrated supernatant fraction to isolate LPF and FHA containing fractions, and (d) isolating at least one fimbrial agglutinogen from the cellular fraction. A vaccine composition may be produced by mixing so-produced LPF, FHA and fimbrial agglutinogens produced.

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The Lancet, Jan. 1984, Sato et al., 122-126.
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