Purification of nystatin in an aqueous system

Details Purification of nystatin in an aqueous system Purification of nystatin in an aqueous system

1977-10-03

1980-01-22

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Processes of making, purifying or recovering

A61K 3500

Patent

active

041850920

ABSTRACT:
Crude, partially purified or contaminated nystatin is purified by suspending the nystatin starting material in water; extracting its activity with sodium lauryl sulfate; adding a chlorinated hydrocarbon solvent; and adding an acid-addition salt of an amine to yield an amorphous precipitate of the nystatin.

REFERENCES:
patent: 3332844 (1967-07-01), Vandeputte et al.
patent: 4006222 (1977-02-01), Metzger

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