Purification of nystatin

Details Purification of nystatin Purification of nystatin

1975-10-20

1977-02-01

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Processes of making, purifying or recovering

A61K 3500

Patent

active

040062228

ABSTRACT:
Crude, partially purified, or contaminated nystatin is purified by suspending the nystatin starting material in a lower alkanol, treating the suspension with an organic acid, filtering the suspension to remove residual solids, adding a chlorinated hydrocarbon solvent to the alkanol filtrate, neutralizing the mixture, and precipitating the nystatin by the addition of water.

REFERENCES:
patent: 2865807 (1958-12-01), Dutcher et al.
patent: 3332844 (1967-07-01), Vandeputte et al.
patent: 3517100 (1970-06-01), Renella
patent: 3517101 (1970-06-01), Esse

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