Purification of mefloquin hydrochloride

Details Purification of mefloquin hydrochloride Purification of mefloquin hydrochloride

1983-04-04

1985-03-26

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40302

Patent

active

045074828

ABSTRACT:
A method for obtaining mefloquin hydrochloride, erythro-.alpha.-2-piperidyl-2,8-bis-(trifluoromethyl)-4-quinolinemethanol hydrochloride, from mixtures of erythro-and threo-.alpha.-2-piperidyl-2,8-bis-(trifluoromethyl)-4-quinolinemethanol hydrochloride by treatment with aqueous methanol or ethanol. The thermodynamically most stable form is obtained by treatment with an alcohol/water mixture for a long period of time.

REFERENCES:
Chien et al., J. Med. Chem. (1976), vol. 19, pp. 170-172.

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