Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
2000-01-26
2000-12-05
Trinh, Ba K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549263, C07D30512
Patent
active
061569119
ABSTRACT:
The present invention relates to a method for the purification of the lipstatin. Impurities are removed from a lipstatin preparation by: a) mixing the preparation with a polar phase and to form a first two phase system in which the ratio of the lipstatin to the non-polar impurities in the polar phase is greater than in the preparation, and separating the phases from the first two phase system and collecting the lipstatin-enriched polar phase, and b) i) diluting the lipstatin-enriched polar phase from step a) with water to form a diluted lipstatin-enriched polar phase containing the polar solvent in a percentage of at least seventy percent of the polar phase and lower than in the lipstatin-enriched polar phase from step a), and mixing the diluted lipstatin-enriched polar phase with a second non-polar phase, the second non-polar phase being the same non-polar solvent as the first non-polar phase in the same or greater relative amount to the polar phase as in the first two phase system; or ii) mixing the lipstatin-enriched polar phase from step a) with a second non-polar phase, the second non-polar phase being the same non-polar solvent as the first non-polar phase in a greater relative amount to the polar phase as in the first two phase system; to form a second two phase system in which the ratio of the lipstatin to the polar impurities in the second non-polar phase is greater than in the lipid-enriched polar phase from step a), and separating the phases from the second two phase system and collecting the lipstatin-enriched second non-polar phase.
REFERENCES:
patent: 4598089 (1986-07-01), Hadvary et al.
Doswald Stephan
Kupfer Ernst
Steinbauer Gerhard
Steinwender Erich
Epstein William H.
Hoffmann-La Roche Inc.
Johnston George W.
Parise John P.
Trinh Ba K.
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