Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-05-19
1992-11-10
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303892, 5303911, 5303915, 53038823, 530351, 530402, 530403, 530404, 530405, 530406, 530409, 530410, 530411, 530412, 530413, 530810, 530811, 530812, 530813, 530814, 530417, 530422, 435 71, 435 78, 435 691, 436501, 436518, 436524, 436527, 436528, 436529, 436530, 536 56, 536112, C07K 1500, C07K 320, C07K 1700, G01N 3350
Patent
active
051625032
ABSTRACT:
Methods are provided for the purification of interleukin-2 (IL-2) from a wide variety of sources, including synthetic mixtures, culture medium conditioned by natural IL-2 producing cells, and mammalian and bacterial recombinant IL-2 expression systems. The methods of the invention employ IL-2 receptor-affinity adsorbents in which soluble IL-2 receptors have been immobilized on solid supports. Through the use of these affinity adsorbents, highly purified IL-2 can be produced in a single step from bacterial extracts or conditioned medium. The IL-2 thus purified is largely free of aggregated forms, which are often present when other purification methods are used.
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Bailon Pascal
Smart John E.
Weber David V.
Draper Garnette D.
Epstein William H.
Gould George M.
Hoffmann-La Roche Inc.
Rocha Patricia S.
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