Purification of inosine from guanosine

Details Purification of inosine from guanosine Purification of inosine from guanosine

1988-12-13

1990-09-18

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, 536 26, C07H 19167, C07H 1916

Patent

active

049580175

ABSTRACT:
An industrially advantageous process for producing an inosine-guanosine mixture having a higher weight ratio of guanosine/inosine than a starting mixture of nucleoside crystals and inosine subtantially free of guanosine from which comprises adjusting an aqueous fluid containing 10 to 30% by weight/volume of a nucleoside mixture to a pH of 9.1 to 9.5, wherein the total amount of inosine and guanosine is more than 95% by weight based on dry matters and the weight ratio of guanosine/inosine is 0.5 to 1, separating the resultant solids and then crystallizing inosine from the resulting solution.

REFERENCES:
Chemical Abstracts 90:138156v (Sugiyama et al. Jpn. Kokai Tokkyo Koho 78,124,688).
Derwent Abstract Acc. No. 78-88573A/49 (Sugiyama et al. Jpn. Kokai Tokkyo Koho 78,124,688).

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