Purification of influenza sub-unit vaccine

Details Purification of influenza sub-unit vaccine Purification of influenza sub-unit vaccine

1981-01-22

1982-04-27

Rosen, Sam

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Recovery or purification

424 89, C12N 702

Patent

active

043271820

ABSTRACT:
A-influenza sub-unit vaccine is provided free from contaminants from A-influenza virus-containing allantoic fluid by a combination of selective membrane filtration and chemical splitting of the virus. The allantoic fluid first is freed of undesired particulate matter dimensioned smaller and larger than the virus and also of undesired dissolved matter. The virus then is chemically treated to split off the HA and NA units. Thereafter, the residual virus body, undesired particulates of same particle size as the virus, and a surfactant used in the chemical treatment are eliminated by selective membrane filtration. The procedure is much less costly and simpler to effect than prior art procedures.

REFERENCES:
patent: 3514374 (1970-05-01), McAleer et al.
patent: 3547779 (1970-12-01), Machlowitz et al.

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