Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Reexamination Certificate
2005-01-13
2008-08-05
Saunders, David A (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
C530S413000
Reexamination Certificate
active
07408030
ABSTRACT:
An immunoglobulin binding peptide having the general formula, from amino terminus to carboxy terminus, of Z-R1—R2—R3—R4—R5—R6—X, is described, wherein: R1is H or Y; R2is a hydrophobic, preferentially aromatic, amino acid (for example W, F, Y, V); R3is a positively charged or aromatic amino acid (for example R, H, F, W); R4is a hydrophobic or positively charged amino acid (for example G, Y, R, K, L); R5is a positively charged or aromatic amino acid (for example W, F, R, H, Y); R6a random amino acid but preferably hydrophobic or negatively charged (for example V, W, L, D, H); X is present or absent and when present is a linking group; and Z is present or absent and when present is a capping group bonded to the N terminus of R1; and wherein the amino acids of said peptide are in D form, L form, or a combination thereof. Methods of using such peptides for the purification of Immunoglobulins are also described.
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Carbonell Ruben
Gurgel Patrick
Yang Haiou
Myers Bigel Sibley & Sajovec P.A.
North Carolina State University
Saunders David A
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