Purification of hepatitis B surface antigen

Details Purification of hepatitis B surface antigen Purification of hepatitis B surface antigen

1974-01-31

1976-11-30

Meyers, Albert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

195 17, 210DIG23, 260112B, 424 12, 424 86, 424 89, A61K 3912, C07G 7028, C12K 700

Patent

active

039948706

ABSTRACT:
After a polyethylene glycol purification procedure, virus particles, viral components and virus associated particles having concanavalin A binding sites are further purified by subjecting such particles or components to affinity chromatography utilizing insoluble concanavalin A as a chromatography adsorbent and an eluant capable of interacting with concanavalin A to thereby inhibit the binding of the virus particles or components to the insoluble concanavalin A. Specifically, the insoluble concanavalin A may be concanavalin A linked to agarose beads and the eluant may be methyl-.alpha.-D-mannopyranoside. Specifically, these procedures may be utilized to purify hepatitis B antigen (HB Ag) particles.

REFERENCES:
stewart, et al., Chem. Abst. vol. 79 (1973), p. 15553n.
Neurath et al., Chem. Abst. vol. 79 (1973), p. 76761a.
Cawley, AJCP, vol. 57, Feb., 1972, p. 253.
Aspberg, Acta Chem. Scand., vol. 24, 1970, pp. 1839-1841.
Lloyd, Arch. Biochem. Biophys. vol. 137, 1970, p. 460.
Tripatzis, Nature, vol. 231, May 28, 1971, pp. 266-267.
Grabow, The J. of Inf. Dis., vol. 127, Feb. 1973, pp. 183-186.
Neurath, PSEBM, vol. 143, 1973, pp. 440-445.

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