Purification of gammaglobulin derivative

Details Purification of gammaglobulin derivative Purification of gammaglobulin derivative

1979-11-30

1981-11-24

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, C07G 700, A61K 3900

Patent

active

043023843

ABSTRACT:
Process for the production of a highly purified S-sulfonated gammaglobulin by treating an S-sulfonated gammaglobulin obtained by sulfonating a conventional gammaglobulin with an ion exchanger in a buffer solution for development, and thereby absorbing single molecular S-sulfonated gammaglobulin thereto, and eluting the single molecular S-sulfonated gammaglobulin with a buffer solution for elution. This process can give the desired S-sulfonated gammaglobulin having a high content of single molecule and an extremely small anticomplementary activity (e.g. CH.sub.50 of 10% or less) and also an excellent shaking stability from the conventional gammaglobulin in an industrial scale.

REFERENCES:
patent: 3869436 (1975-03-01), Falksveden
patent: 4059571 (1977-11-01), Tomibe et al.
patent: 4100149 (1978-07-01), Meiller et al.
Habeeb et al., Vox Sang., vol. 31, pp. 423-434 (1976).
Habeeb et al., Vox Sang., vol. 32, pp. 143-158 (1977).
Chemical Abstracts, vol. 86, Abstract No. 104271f, Masuho et al., "Develont of an Intravenous .gamma.-6l," 1977.

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